Spermidine is simple ingredient that is turning out to have some remarkable benefits for heathy aging and longevity.
What is spermidine?
Spermidine is a polyamine found naturally in cells and certain whole foods. It is also available in supplement form. Predicted to be the longevity supplement of 2022 by lifespan expert Dr David Sinclair, spermidine is fast becoming a big name on the supplement scene. Taken regularly, the supplement can have a significant impact on health and lifespan. By mimicking the effects that caloric restriction has on cells in the body, it induces autophagy, the process of cellular renewal thought to have antiaging benefits. As we age, our spermidine levels as well as our rate of autophagy decline, leaving cells more exposed to damage from the hallmarks of aging. Maintaining our spermidine levels as we age by eating foods high in spermidine or taking supplements should be a priority in protecting future longevity.
Where is spermidine found?
- Vegetables – Getting your five-a-day can have additional benefits as spermidine is found in a rich harvest of whole foods from fresh green pepper, cauliflower, broccoli and mushrooms. Some of these ingredients are particularly common to the longevity-friendly Mediterranean diet and may go some way to explaining its unparalleled health benefits.
- A variety of cheeses
- Wheatgerm – Spermidine is also available in high concentrations in the health food wheat germ, a common ingredient in nutritional and longevity supplements.
- Soybean products – Even higher amounts are found in soybean products common to the Japanese diet like natto, shitake mushroom, amaranth grain and durian.
How does spermidine actually work inside the body?
spermidine induces autophagy, the process of cellular rejuvenation, through the TOR kinase pathway. Autophagy occurs naturally in cells as it regulates cellular metabolism. Autophagy also balances nutrients during cell stress so can be can be accelerated by fasting or by caloric restriction mimetics (CRMs) like spermidine that mimic fasting’s effects on the body [1]. During autophagy, cells reuse their old or damaged organelles to achieve cellular renewal and its antiaging benefits. Indeed, autophagy is thought to limit inflammation and oxidative stress, the main culprits involved in aging and related diseases.
How to increase the spermidine in the body？
This can be rectified by eating foods high in spermidine and taking supplements, thus limiting the impact of aging on longevity. While it is generally beneficial to enjoy a varied diet rich in whole foods, the most effective way to attenuate declining spermidine levels is by taking longevity supplements. Spermidine supplements are available in powder or capsules form and when taken regularly can effectively improve longevity.
Spermidine benefits
There are some potential health benefits from supplementing or eating enough spermidine in the diet. Even better, it may also influence aging and support healthy longevity.
- Reduces Cancer Mortality – Studies found that eating a spermidine-rich diet could potentially reduce the risk of cancer-related mortality among humans.
- Protects Against Cardiovascular Disease – Regularly taking spermidine intake can reduce your blood pressure levels and lower the risk of cardiac hypertrophy, heart failure, and other cardiovascular diseases.
- Combats Neurodegenerative Disease – Taking spermidine supplementally can reverse neuron damages caused by inflammation, oxidative stress, and ischemia. As a result, it can decrease the risk of suffering neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.
- Slows Down Aging – One studyfound that higher survival rates among humans were linked to increased spermidine intake through dietary sources such as supplementations.
Is spermidine safe?
Considering that spermidine is a naturally-occurring product in the body, it is deemed perfectly safe for health. Additionally, clinical trials suggest that the supplement has no known side effects.
XI’AN AOGU BIOTECH CO.,LTD is devoted into the research and innovation in natural nutritional supplements ingredients. Our own factory and lab with the strict quality control system to ensure quality stability and real price of Spermidine. At the same time, we have our own source for the raw material to make sure the production ability.